Hydroxoiridium/Chiral Diene Complexes as Effective Catalysts for Asymmetric Annulation of α-Oxo- and Iminocarboxamides with 1,3-Dienes

Miyuki Hatano; Takahiro Nishimura

doi:10.1002/anie.201505382

Hydroxoiridium/Chiral Diene Complexes as Effective Catalysts for Asymmetric Annulation of α-Oxo- and Iminocarboxamides with 1,3-Dienes

Angew Chem Int Ed Engl. 2015 Sep 7;54(37):10949-52. doi: 10.1002/anie.201505382. Epub 2015 Jul 27.

Authors

Miyuki Hatano¹, Takahiro Nishimura²

Affiliations

¹ Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502 (Japan).
² Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502 (Japan). tnishi@kuchem.kyoto-u.ac.jp.

PMID: 26220276
DOI: 10.1002/anie.201505382

Abstract

The asymmetric [3+2] annulation of α-oxo- and α-iminocarboxamides with 1,3-dienes catalyzed by hydroxoiridium/chiral diene complexes was realized, giving high yields of the corresponding γ-lactams with high enantioselectivity.

Keywords: [3+2] annulation; asymmetric synthesis; carboxamides; chiral diene; iridium.