The Positive Predictive Value of Lyme Elisa for the Diagnosis of Lyme Disease in Children

Pediatr Infect Dis J. 2015 Nov;34(11):1260-2. doi: 10.1097/INF.0000000000000858.


By using a Lyme enzyme-linked immunosorbent assay (ELISA), we demonstrated that high ELISA index values are strongly predictive of Lyme disease. In children with clinical presentations consistent with Lyme disease, ELISA index values ≥3.0 had a positive predictive value of 99.4% (95% confidence interval: 98.1-99.8%) for Lyme disease, making a supplemental Western immunoblot potentially unnecessary.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Child
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay / methods*
  • Female
  • Humans
  • Lyme Disease / diagnosis*
  • Male
  • Predictive Value of Tests
  • Retrospective Studies