Validation and cross-cultural adaptation of sexual dysfunction modified scale in multiple sclerosis for Brazilian population

Arq Neuropsiquiatr. 2015 Aug;73(8):681-7. doi: 10.1590/0004-282X20150078.


Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). These patients suffer from various comorbidities, including sexual dysfunction (SD). The lesions of MS may affect regions of the CNS along the pathway of sexual response. The Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19) is a scale that assesses sexual dysfunction. Adapt and validate the MSISQ-19 to Brazilian patients with MS. 204 individuals were evaluated, 134 patients with MS and 70 healthy persons for the control group. It was determined reproducibility, validity, internal consistency and sensitivity of the MSISQ-19-BR. Among patients with MS, 54.3% of male and 71.7% of female presented some kind of SD. In the control group the results were 12.5% and 19.5%, respectively. The MSISQ-19-BR is reproducible, reliable and valid for the Brazilian population and may be used as a tool for assessing the impact of sexual dysfunction in patients with MS.

Publication types

  • Validation Study

MeSH terms

  • Adult
  • Brazil
  • Case-Control Studies
  • Cross-Cultural Comparison
  • Cultural Characteristics
  • Disability Evaluation
  • Female
  • Humans
  • Language
  • Male
  • Middle Aged
  • Multiple Sclerosis / physiopathology*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sex Factors
  • Sexual Dysfunction, Physiological / physiopathology*
  • Statistics, Nonparametric
  • Surveys and Questionnaires / standards*
  • Translations