Anti-Bioadhesive Coating Based on Easy to Make Pseudozwitterionic RAFT Block Copolymers for Blood-Contacting Applications

Macromol Biosci. 2016 Jan;16(1):57-62. doi: 10.1002/mabi.201500185. Epub 2015 Jul 29.


Amphiphilic diblock copolymer containing randomly distributed positive and negative charged monomers are synthesized using RAFT polymerization technique to be used as anti-bioadhesion coatings for hydrophobic surfaces. Quaternized 2-(dimethylamino) ethyl methacrylate and potassium 3-sulfopropyl methacrylate (P[qDMAEMA-co-KSPMA]) are randomly polymerized to yield an anti-bioadhesion block which is, in one pot, copolymerized with styrene as an anchoring block. This copolymer has demonstrated high anti-bioadhesion properties to avoid the blood clotting in medical devices through a simple and facile approach to preparation of pseudozwitterionic copolymers.

Keywords: RAFT; anti-bioadhesion; blood protein; copolymer; pseudozwitterionic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Blood*
  • Coated Materials, Biocompatible
  • Humans
  • Methacrylates / chemistry
  • Polymerization
  • Polymers / chemistry*
  • Styrene / chemistry


  • 3-sulfopropyl methacrylate
  • Coated Materials, Biocompatible
  • Methacrylates
  • Polymers
  • Styrene
  • 2-(dimethylamino)ethyl methacrylate