Resting-state functional brain networks in Parkinson's disease

CNS Neurosci Ther. 2015 Oct;21(10):793-801. doi: 10.1111/cns.12417. Epub 2015 Jul 30.


The network approach is increasingly being applied to the investigation of normal brain function and its impairment. In the present review, we introduce the main methodological approaches employed for the analysis of resting-state neuroimaging data in Parkinson's disease studies. We then summarize the results of recent studies that used a functional network perspective to evaluate the changes underlying different manifestations of Parkinson's disease, with an emphasis on its cognitive symptoms. Despite the variability reported by many studies, these methods show promise as tools for shedding light on the pathophysiological substrates of different aspects of Parkinson's disease, as well as for differential diagnosis, treatment monitoring and establishment of imaging biomarkers for more severe clinical outcomes.

Keywords: Functional magnetic resonance imaging; Neural networks; Parkinson's disease; Resting-state.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain / physiopathology*
  • Functional Neuroimaging / methods*
  • Humans
  • Neural Pathways / physiopathology
  • Parkinson Disease / physiopathology*
  • Rest