The Effects of Supplementation with a Vitamin and Mineral Complex with Guaraná Prior to Fasted Exercise on Affect, Exertion, Cognitive Performance, and Substrate Metabolism: A Randomized Controlled Trial

Nutrients. 2015 Jul 27;7(8):6109-27. doi: 10.3390/nu7085272.


Exercise undertaken in a fasted state can lead to higher post-exercise mental fatigue. The administration of a vitamin and mineral complex with guaraná (MVM + G) has been shown to attenuate mental fatigue and improve performance during cognitively demanding tasks. This placebo-controlled, double-blind, randomized, balanced cross-over study examined the effect of MVM + G consumed prior to morning exercise on cognitive performance, affect, exertion, and substrate metabolism. Forty active males (age 21.4 ± 3.0 year; body mass index (BMI) 24.0 ± 2.4 kg/m2; maximal oxygen consumption (V̇O2max) 57.6 ± 7.3 mL/min/kg) completed two main trials, consuming either MVM + G or placebo prior to a 30-min run at 60% V̇O2max. Supplementation prior to exercise led to a small but significant reduction in Rating of Perceived Exertion (RPE) during exercise compared to the placebo. The MVM + G combination also led to significantly increased accuracy of numeric working memory and increased speed of picture recognition, compared to the placebo. There were no significant effects of supplementation on any other cognitive or mood measures or on substrate metabolism during exercise. These findings demonstrate that consuming a vitamin and mineral complex containing guaraná, prior to exercise, can positively impact subsequent memory performance and reduce perceived exertion during a moderate-intensity run in active males.

Keywords: cognition; exercise; guaraná; memory; micronutrients; mood.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Affect / drug effects*
  • Cognition / drug effects*
  • Cross-Over Studies
  • Dietary Supplements*
  • Double-Blind Method
  • Fasting
  • Humans
  • Male
  • Memory / drug effects
  • Mental Fatigue / prevention & control*
  • Micronutrients / pharmacology*
  • Minerals / pharmacology
  • Oxygen Consumption
  • Paullinia*
  • Physical Endurance / drug effects
  • Physical Exertion / drug effects
  • Plant Extracts / pharmacology
  • Recognition, Psychology / drug effects
  • Running / physiology*
  • Running / psychology
  • Vitamins / pharmacology
  • Young Adult


  • Micronutrients
  • Minerals
  • Plant Extracts
  • Vitamins