Ratcheting of RNA polymerase toward structural principles of RNA polymerase operations

Transcription. 2015;6(3):56-60. doi: 10.1080/21541264.2015.1059922.


RNA polymerase (RNAP) performs various tasks during transcription by changing its conformational states, which are gradually becoming clarified. A recent study focusing on the conformational transition of RNAP between the ratcheted and tight forms illuminated the structural principles underlying its functional operations.

Keywords: RNA polymerase; structure-function relationship; transcription; transcription factor; transcription regulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteria / classification
  • Bacteria / enzymology
  • Bacteria / metabolism*
  • DNA-Directed RNA Polymerases / chemistry
  • DNA-Directed RNA Polymerases / metabolism*
  • Gene Expression Regulation
  • Models, Molecular
  • Protein Conformation
  • Transcription, Genetic*


  • DNA-Directed RNA Polymerases