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. 2015 Sep;81(14):1285-9.
doi: 10.1055/s-0035-1546257. Epub 2015 Jul 30.

Pestalpolyols A-D, Cytotoxic Polyketides from Pestalotiopsis sp. cr013

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Pestalpolyols A-D, Cytotoxic Polyketides from Pestalotiopsis sp. cr013

Jing Li et al. Planta Med. 2015 Sep.

Abstract

Four novel polyketides, named pestalpolyols A (1), B (2), C (3), and D (4), were isolated from solid fermentation products of Pestalotiopsis sp. cr013. Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry experiments, and the absolute configuration was confirmed by single-crystal X-ray diffraction analysis using the anomalous scattering of Cu Kα radiation. The inhibitory activities of compounds 1, 2, and 4 against five human tumor lines were tested in vitro, and showed IC50 values 2.3-31.2 µM.

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