Pestalpolyols A-D, Cytotoxic Polyketides from Pestalotiopsis sp. cr013
- PMID: 26227504
- DOI: 10.1055/s-0035-1546257
Pestalpolyols A-D, Cytotoxic Polyketides from Pestalotiopsis sp. cr013
Abstract
Four novel polyketides, named pestalpolyols A (1), B (2), C (3), and D (4), were isolated from solid fermentation products of Pestalotiopsis sp. cr013. Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry experiments, and the absolute configuration was confirmed by single-crystal X-ray diffraction analysis using the anomalous scattering of Cu Kα radiation. The inhibitory activities of compounds 1, 2, and 4 against five human tumor lines were tested in vitro, and showed IC50 values 2.3-31.2 µM.
Georg Thieme Verlag KG Stuttgart · New York.
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