Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population

Dermatology. 2015;231(3):239-44. doi: 10.1159/000433597. Epub 2015 Jul 24.

Abstract

Background: It has been suggested that the single nucleotide polymorphism (SNP) of the CYP19A1 gene encoding aromatase may affect the development of female pattern hair loss (FPHL).

Objective: Our aim was to investigate the association of CYP19A1 gene SNPs with FPHL in a Chinese population.

Methods: Two hundred Chinese Han patients with FPHL and 200 controls were enrolled into our study. SNaPshot technology was used to detect CYP19A1 gene candidate SNPs.

Results: The allele frequencies and distributions of rs6493497 and rs7176005 were significantly different between FPHL and control subjects (p < 0.001 and p < 0.001 vs. p < 0.001 and p = 0.003).

Conclusion: The rs6493497 and rs7176005 SNPs of the CYP19A1 gene may be genetic markers that influence the risk of FPHL in this Chinese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alopecia / epidemiology
  • Alopecia / genetics
  • Alopecia / metabolism
  • Aromatase / genetics*
  • Aromatase / metabolism
  • China / epidemiology
  • DNA / genetics*
  • Female
  • Gene Frequency
  • Genetic Markers
  • Genotype
  • Haplotypes
  • Humans
  • Incidence
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Population Surveillance / methods*

Substances

  • Genetic Markers
  • DNA
  • Aromatase
  • CYP19A1 protein, human