Inflammation and hypoxia in the kidney: friends or foes?

Kidney Int. 2015 Aug;88(2):213-5. doi: 10.1038/ki.2015.89.

Abstract

Hypoxic injury is commonly associated with inflammatory-cell infiltration, and inflammation frequently leads to the activation of cellular hypoxia response pathways. The molecular mechanisms underlying this cross-talk during kidney injury are incompletely understood. Yamaguchi and colleagues identify CCAAT/enhancer-binding protein δ as a cytokine- and hypoxia-regulated transcription factor that fine-tunes hypoxia-inducible factor-1 signaling in renal epithelial cells and thus provide a novel molecular link between hypoxia and inflammation in kidney injury.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Protein-delta / genetics*
  • Gene Expression Regulation*
  • Humans
  • Hypoxia / metabolism*
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
  • Kidney / pathology*
  • Male
  • Nephritis / metabolism*

Substances

  • Hypoxia-Inducible Factor 1, alpha Subunit
  • CCAAT-Enhancer-Binding Protein-delta