1 Department of Cancer Medicine, Peter MacCallum Cancer Centre , East Melbourne, VIC , Australia ; Department of Pathology, University of Melbourne , Parkville, VIC , Australia ; Department of Medicine, St Vincent's Hospital, University of Melbourne , Fitzroy, VIC , Australia ; Sir Peter MacCallum Department of Oncology, University of Melbourne , East Melbourne, VIC , Australia ; Molecular Oncology Laboratory, Oncogenic Signaling and Growth Control Program, Peter MacCallum Cancer Centre , East Melbourne, VIC , Australia ; Translational Research Laboratory, Cancer Therapeutics Program, Peter MacCallum Cancer Centre , East Melbourne, VIC , Australia.