[OCT Angiography - Is this the Future for Macular Diagnosis?]

Klin Monbl Augenheilkd. 2015 Sep;232(9):1069-76. doi: 10.1055/s-0041-102345. Epub 2015 Aug 4.
[Article in German]


Recent developements in OCT technology using high speed acquisition and calculation of consecutive scans (SSADA = split spectrum amplitude decorrelation algorithm) have resulted in the possibility to demonstrate retinal and choroidal vessels in the macula. This new technology of "OCT angiography" thus allows the non-invasive and rapid (within seconds) reconstruction of the three-dimensional structure of the retinal and choroidal vascularisation. There are still limitations caused by movement artefacts, superposition of superficial retinal vessels at the RPE level or insufficient three-dimensional imaging, but the first experience with this new method and especially the correlations with the current standard diagnostic procedure fluorescein angiography shows that especially for vascular changes which are predominantly in one retinal layer (e.g., the inner retina) like in diabetic retinopathy or retinal vein occlusions, a very good correlation can be seen. Also in MacTel type 2 patients the proposed vascular changes in the deeper capillary network of the retina can be visualised very well with OCT angiography. In contrast, more three-dimensional vascular changes like the neovascular complex in exsudative AMD need a more sophisticated diagnostic analysis strategy, which has still to be developed. However, the first experience also demonstrates that fluorescein angiographic differentiation can also be seen in OCT angiography. In addition, the new technology gives additional information about the choroidal and outer retinal changes in these pathologies, which may result in a better understanding of the underlying pathologies.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Angiography / methods*
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Macular Degeneration / pathology*
  • Retinal Vessels / pathology*
  • Retinoscopy / methods*
  • Tomography, Optical Coherence / methods*