Cerebral Perfusion Measurements in Elderly with Hypertension Using Arterial Spin Labeling

PLoS One. 2015 Aug 4;10(8):e0133717. doi: 10.1371/journal.pone.0133717. eCollection 2015.

Abstract

Purpose: The current study assesses the feasibility and value of crushed cerebral blood flow (CBFcrushed) and arterial transit time (ATT) estimations for large clinical imaging studies in elderly with hypertension.

Material and methods: Two pseudo-continuous arterial spin labeling (ASL) scans with (CBFcrushed) and without flow crushers (CBFnon-crushed) were performed in 186 elderly with hypertension, from which CBF and ATT maps were calculated. Standard flow territory maps were subdivided into proximal, intermediate and distal flow territories, based on the measured ATT. The coefficient of variation (CV) and physiological correlations with age and gender were compared between the three perfusion parameters.

Results: There was no difference in CV between CBFcrushed and CBFnon-crushed (15-24%, p>0.4) but the CV of ATT (4-9%) was much smaller. The total gray matter correlations with age and gender were most significant with ATT (p = .016 and p<.001 respectively), in between for CBFcrushed (p = .206 and p = .019) and least significant for CBFnon-crushed (p = .236 and p = .100).

Conclusion: These data show the feasibility and added value of combined measurements of both crushed CBF and ATT for group analyses in elderly with hypertension. The obtained flow territories provide knowledge on vascular anatomy of elderly with hypertension and can be used in future studies to investigate regional vascular effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blood Flow Velocity
  • Cerebral Arteries / physiopathology*
  • Cerebrovascular Circulation*
  • Feasibility Studies
  • Female
  • Gray Matter / blood supply
  • Humans
  • Hypertension / physiopathology*
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Male
  • Spin Labels*
  • Subtraction Technique

Substances

  • Spin Labels

Grant support

This study was carried out within the context of the preDIVA study which was supported by the Dutch Ministry of Health, Welfare and Sports (grant# 50-50110-98-020), the Dutch Innovation fund of collaborative health insurances grant# 05-234 and the Netherlands Organization for Health Research and Development (grant# 62000015). The MRI substudy was supported by the "Internationale Stichting Alzheimer Onderzoek" (ISAO, grant# 10507) and the Dutch non-governmental organization NutsOhra. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.