Bordetella pertussis, B. parapertussis, vaccines and cycles of whooping cough

Pathog Dis. 2015 Oct;73(7):ftv055. doi: 10.1093/femspd/ftv055. Epub 2015 Aug 4.


Whooping cough is a vaccine-preventable disease due to Bordetella pertussis and B. parapertussis. This highly contagious respiratory disease occurs through epidemic cycles every 3-5 years and vaccination did not change this frequency. Models suggest that the cyclic increase of susceptibles is linked to demographic differences and different vaccine coverage. However, differences in surveillance of the disease as well as adaptation of the agents of the disease to their human hosts and to vaccine pressure might also play an important role. These parameters are discussed in this review.

Keywords: Bordetella parapertussis; Bordetella pertussis; polymorphism; vaccine; whooping cough.

Publication types

  • Review

MeSH terms

  • Bordetella parapertussis / immunology*
  • Bordetella pertussis / immunology*
  • Humans
  • Pertussis Vaccine / administration & dosage*
  • Pertussis Vaccine / immunology*
  • Whooping Cough / epidemiology*
  • Whooping Cough / prevention & control*


  • Pertussis Vaccine