NNMT: A Bad Actor in Fat Makes Good in Liver

Cell Metab. 2015 Aug 4;22(2):200-1. doi: 10.1016/j.cmet.2015.07.017.


High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.

Publication types

  • Comment

MeSH terms

  • Animals
  • Female
  • Humans
  • Liver / metabolism*
  • Male
  • Nicotinamide N-Methyltransferase / physiology*
  • Sirtuin 1 / physiology*


  • Nicotinamide N-Methyltransferase
  • Sirtuin 1