Whether it's a single tooth or multiple teeth, tooth loss has esthetic, functional, and health implications. Replacing multiple teeth can be especially complicated due to the loss of surrounding structures, often making it necessary to use additional procedures--eg, bone grafting--to solve the problems that arise. Fortunately, modern techniques and materials in dentistry enable clinicians to replace and mimic lost teeth in a realistic, healthy, and functional way like no other field in medicine. This report discusses two cases that involve multiple subspecialties working synergistically to accomplish ideal tooth replacement and emphasizes the importance of proper diagnosis, treatment planning, and execution of surgical and restorative therapy to achieve optimal results.