Translational Control of the HIV Unspliced Genomic RNA

Viruses. 2015 Aug 4;7(8):4326-51. doi: 10.3390/v7082822.


Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP.

Keywords: DDX3; HIV-1; IRES; Rev; cap-dependent translation; nuclear export.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • Gene Expression Regulation, Viral*
  • HIV-1 / genetics
  • HIV-1 / physiology*
  • HIV-2 / genetics
  • HIV-2 / physiology*
  • Host-Pathogen Interactions*
  • Humans
  • Protein Biosynthesis*
  • RNA, Viral / metabolism*
  • Ribonucleoproteins / metabolism
  • Viral Proteins / metabolism
  • Virus Replication*


  • RNA, Viral
  • Ribonucleoproteins
  • Viral Proteins