Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis

Clin Immunol. 2015 Dec;161(2):170-3. doi: 10.1016/j.clim.2015.07.013. Epub 2015 Aug 3.


Aim: To compare different variables among (S)CID patients diagnosed in the USA and Kuwait.

Methods: Review of patients registered in The US Immune Deficiency Network registry or Kuwait National PID Registry between 2004 and 2014.

Results: Totals of 98 and 69 (S)CID patients were registered during the study period in the USIDNET registry and the KNPIDR, respectively. The average annual incidence rate for the period 2004-2014 of (S)CID in children in Kuwait was 13.01/100,000 children, with an estimated occurrence of 1/7500 live births. There were differences between the two countries in the following variables: age at onset and diagnosis, family history of (S)CID, parental consanguinity, and outcome. More than 14% of (S)CID patients from USIDNET registry were diagnosed through newborn screening.

Conclusions: Patients' characteristics and molecular causes of S(CID) are different between USA and Kuwait. NBS for SCID should be started in countries where the incidence of (S)CID is high.

Keywords: Combined immunodeficiency; Epidemiology; Genetics; Incidence; Newborn screening; Prevalence; Registry.

MeSH terms

  • Age of Onset
  • Child
  • Humans
  • Immunologic Deficiency Syndromes / diagnosis*
  • Immunologic Deficiency Syndromes / epidemiology*
  • Infant, Newborn
  • Kuwait / epidemiology
  • Neonatal Screening / methods
  • Pathology, Molecular / methods
  • Registries
  • United States / epidemiology