Fluconazole and Voriconazole Resistance in Candida parapsilosis Is Conferred by Gain-of-Function Mutations in MRR1 Transcription Factor Gene

Antimicrob Agents Chemother. 2015 Oct;59(10):6629-33. doi: 10.1128/AAC.00842-15. Epub 2015 Jul 27.


Candida parapsilosis is the second most prevalent fungal agent causing bloodstream infections. Nevertheless, there is little information about the molecular mechanisms underlying azole resistance in this species. Mutations (G1747A, A2619C, and A3191C) in the MRR1 transcription factor gene were identified in fluconazole- and voriconazole-resistant strains. Independent expression of MRR1 genes harboring these mutations showed that G1747A (G583R) and A2619C (K873N) are gain-of-function mutations responsible for azole resistance, the first described in C. parapsilosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Candida / drug effects
  • Candida / genetics
  • Drug Resistance, Fungal
  • Fluconazole / pharmacology*
  • Fungal Proteins / genetics*
  • Fungal Proteins / physiology
  • Gene Expression Regulation, Fungal / drug effects
  • Gene Expression Regulation, Fungal / genetics
  • Molecular Sequence Data
  • Mutation / genetics
  • Transcription Factors / genetics*
  • Transcription Factors / physiology
  • Voriconazole / pharmacology*


  • Fungal Proteins
  • Transcription Factors
  • Fluconazole
  • Voriconazole

Associated data

  • GENBANK/KT160017
  • GENBANK/KT160018
  • GENBANK/KT160019