[Respiratory allergies in children and adolescents: the role of component-resolved diagnosis and specific immunotherapy]

Wien Med Wochenschr. 2015 Sep;165(17-18):347-53. doi: 10.1007/s10354-015-0375-4. Epub 2015 Aug 7.
[Article in German]


Respiratory allergies of children and adolescents are an important issue in allergology. In parallel to increasing prevalence rates also research has rapidly been developing for the last 10 years. Today we can better understand complex systems to improve our diagnostic and therapeutic accuracy. In addition to medical history, skin-prick-testing and analysis of specific IgE to allergen extracts, component resolved diagnosis has gained importance in the last years. While being increasingly helpful in the diagnosis of insect-venom and food-allergies, component-based diagnosis can also improve the management of patients with respiratory allergies. Concerning different therapeutic approaches like allergen-avoidance or symptomatic therapy, specific immunotherapy (SIT) is one of the most interesting therapy-options, as it is still the only causal therapy available. After reasonable patient-selection and the selection of the right allergen and product, SIT has a very good risk/benefit-ration and can induce long-term immuno-tolerance to specific allergens.

Keywords: Allergy; Component-resolved; Diagnosis; Specific immunotherapy; Therapy.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Adolescent
  • Allergens / immunology*
  • Child
  • Desensitization, Immunologic / methods*
  • Epitopes / immunology*
  • Humans
  • Immunoglobulin E / blood*
  • Intradermal Tests
  • Recurrence
  • Respiratory Hypersensitivity / etiology*
  • Respiratory Hypersensitivity / immunology*
  • Respiratory Hypersensitivity / therapy


  • Allergens
  • Epitopes
  • Immunoglobulin E