Preventing stem cell transplantation-associated viral infections using T-cell therapy

Immunotherapy. 2015;7(7):793-810. doi: 10.2217/imt.15.43. Epub 2015 Aug 7.


Hematopoietic stem cell transplantation is the treatment of choice for many hematologic malignancies and genetic diseases. However, viral infections continue to account for substantial post-transplant morbidity and mortality. While antiviral drugs are available against some viruses, they are associated with significant side effects and are frequently ineffective. This review focuses on the immunotherapeutic strategies that have been used to prevent and treat infections over the past 20 years and outlines different refinements that have been introduced with the goal of moving this therapy beyond specialized academic centers.

Keywords: T cells; adoptive immunotherapy; hematopoietic stem cell transplantation; viral infections.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Allografts
  • Genetic Diseases, Inborn / immunology
  • Genetic Diseases, Inborn / therapy*
  • Hematologic Neoplasms / immunology
  • Hematologic Neoplasms / therapy*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immunotherapy / methods*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / transplantation*
  • Virus Diseases / etiology
  • Virus Diseases / immunology
  • Virus Diseases / prevention & control*