Erythropoietin and Neonatal Neuroprotection

Clin Perinatol. 2015 Sep;42(3):469-81. doi: 10.1016/j.clp.2015.04.004. Epub 2015 May 14.


Certain groups of neonates are at high risk of developing long-term neurodevelopmental impairment and might be considered candidates for neuroprotective interventions. This article explores some of these high-risk groups, relevant mechanisms of brain injury, and specific mechanisms of cellular injury and death. The potential of erythropoietin (Epo) to act as a neuroprotective agent for neonatal brain injury is discussed. Clinical trials of Epo neuroprotection in preterm and term infants are updated.

Keywords: Apoptosis; Autophagy; Brain injury; Erythropoietin; Extreme prematurity; Hypoxic ischemic encephalopathy; Necrosis.

Publication types

  • Review

MeSH terms

  • Erythropoietin / therapeutic use*
  • Humans
  • Hypoxia-Ischemia, Brain / prevention & control*
  • Infant, Newborn
  • Neuroprotection*


  • Erythropoietin