Abstract
A general and environmentally responsible method for the formation of amide/peptide bonds in an aqueous micellar medium is described. Use of uronium salt (1-cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium hexafluorophosphate (COMU) as a coupling reagent, 2,6-lutidine, and TPGS-750-M represents mild conditions associated with these valuable types of couplings. The aqueous reaction medium is recyclable leading to low E Factors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Amides / chemistry
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Imines / chemistry
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Indicators and Reagents
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Molecular Structure
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Morpholines / chemistry
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Peptides / chemical synthesis*
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Peptides / chemistry
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Pyridines / chemistry
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Surface-Active Agents / chemistry
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Temperature
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Water / chemistry*
Substances
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1-((1-(cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylaminomorpholinomethylene))methanaminium
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Amides
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Imines
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Indicators and Reagents
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Morpholines
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Peptides
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Pyridines
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Surface-Active Agents
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Water
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2,6-lutidine