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. 2015 Oct:102:101-9.
doi: 10.1016/j.steroids.2015.08.004. Epub 2015 Aug 6.

Nodulisporisteroids C-L, new 4-methyl-progesteroid derivatives from Nodulisporium sp

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Nodulisporisteroids C-L, new 4-methyl-progesteroid derivatives from Nodulisporium sp

Qin Zhao et al. Steroids. 2015 Oct.

Abstract

The fungus Nodulisporium sp. (No. 65-12-7-1), which can produce a rare class of steroids (4-methyl-progesteroids) in rice solid medium, was subjected to a one strain-many compounds (OSMAC) approach. It was found to produce ten new 4-methyl-progesteroid derivatives named nodulisporisteroids C-L (1-10) in potato-dextrose-broth (PDB) medium, which showed that the fungus was a prolific producer of 4-methyl-progesteroids. The structures of 1-10 were elucidated by spectroscopic and X-ray crystallographic analysis. Their cytotoxic activities against five human cancer cell lines had been evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method.

Keywords: 4-Methyl-progesteroid derivatives; Endolichenic fungus; Nodulisporium sp.; Xylariaceae.

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