Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction

Clin Chim Acta. 2015 Oct 23;450:83-9. doi: 10.1016/j.cca.2015.08.002. Epub 2015 Aug 6.

Abstract

Advancing age is a major risk factor for the development of cardiovascular diseases. The aetiology of several cardiovascular disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q10 (CoQ10) acts as both an antioxidant and as an electron acceptor at the level of the mitochondria. Furthermore, in cardiac patients, plasma CoQ10 has been found to be an independent predictor of mortality. Based on the fundamental role of CoQ10 in mitochondrial bioenergetics and its well-acknowledged antioxidant properties, several clinical trials evaluating CoQ10 have been undertaken in cardiovascular disorders of ageing including chronic heart failure, hypertension, and endothelial dysfunction. CoQ10 as a therapy appears to be safe and well tolerated.

Keywords: Coenzyme Q10; Endothelial dysfunction; Heart failure; Hypertension.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / drug effects*
  • Aging / pathology
  • Antioxidants / metabolism
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Endothelial Cells / drug effects*
  • Endothelial Cells / pathology*
  • Heart Failure / drug therapy*
  • Humans
  • Hypertension / drug therapy*
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / metabolism
  • Ubiquinone / pharmacology
  • Ubiquinone / therapeutic use

Substances

  • Antioxidants
  • Ubiquinone
  • coenzyme Q10