[Effects of aloe extracts, aloctin A, on gastric secretion and on experimental gastric lesions in rats]

Yakugaku Zasshi. 1989 May;109(5):335-9. doi: 10.1248/yakushi1947.109.5_335.
[Article in Japanese]

Abstract

Effect of aloctin A, glycoprotein isolated from leaves of Aloe arborescens MILL, on gastric secretion and on acute gastric lesions in rats were examined. Aloctin A given intravenously dose-dependently inhibited the volume of gastric juice, acid and pepsin output in pylorus-ligated rats. Aloctin A given intravenously significantly inhibited the development of Shay ulcers and indomethacin-induced gastric lesions in rats. It also inhibited water-immersion stress lesions induced in pylorus-ligated rats.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Ulcer Agents*
  • Dose-Response Relationship, Drug
  • Gastric Mucosa / metabolism*
  • Lectins / pharmacology*
  • Male
  • Plant Lectins*
  • Rats
  • Rats, Inbred Strains

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anti-Ulcer Agents
  • Lectins
  • Plant Lectins
  • aloctin A