Antibiotic profiling of Clostridium difficile ribotype 176--A multidrug resistant relative to C. difficile ribotype 027

Anaerobe. 2015 Dec;36:88-90. doi: 10.1016/j.anaerobe.2015.07.009. Epub 2015 Aug 6.

Abstract

Antibiotic profiling of twenty Czech Clostridium difficile PCR-ribotype 176 isolates revealed a high level of resistance to erythromycin, ciprofloxacin and moxifloxacin (n = 20) and to rifampicin (n = 13). Accumulation of resistance mechanisms to multiple antibiotics highlight that PCR-ribotype 176 belong to problematic epidemic strains.

Keywords: Clostridium difficile; Erythromycin; Moxifloxacin; PCR-ribotype 176; Resistance; Rifampicin; Thr82Ile.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Base Sequence
  • Clostridioides difficile / classification
  • Clostridioides difficile / drug effects*
  • Clostridioides difficile / genetics
  • Clostridioides difficile / isolation & purification
  • Czech Republic
  • Drug Resistance, Multiple, Bacterial*
  • Enterocolitis, Pseudomembranous / microbiology*
  • Humans
  • Molecular Sequence Data
  • Mutation
  • Ribotyping

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins