Getting the genome in shape: the formation of loops, domains and compartments

Genome Biol. 2015 Aug 10;16(1):154. doi: 10.1186/s13059-015-0730-1.


The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromatin / chemistry*
  • Enhancer Elements, Genetic
  • Gene Expression Regulation
  • Genome*
  • Promoter Regions, Genetic
  • Transcription Factors / metabolism
  • Transcription, Genetic*


  • Chromatin
  • Transcription Factors