Screening mammography-detected ductal carcinoma in situ: mammographic features based on breast cancer subtypes

Clin Imaging. 2015 Nov-Dec;39(6):983-6. doi: 10.1016/j.clinimag.2015.06.006. Epub 2015 Jul 16.

Abstract

We evaluated the mammographic and histopathologic features of screening mammography-detected ductal carcinoma in situ (DCIS) based on the breast cancer subtypes determined by immunohistochemistry. A total of 94 patients with 94 screening mammography-detected DCIS were included in this study. Mammographically, human epidermal growth factor receptor 2 (HER2)-positive DCIS was more commonly associated with calcifications than estrogen receptor (ER)-positive and triple-negative DCIS (P=.003). Histopathologically, HER2-positive DCIS and triple-negative DCIS were associated with high nuclear grade (P ≤ .001) and comedo necrosis (P ≤ .001) than ER-positive DCIS.

Keywords: Breast; Calcification; ER; HER2; Mammography.

MeSH terms

  • Adult
  • Breast Neoplasms / diagnostic imaging*
  • Carcinoma, Ductal, Breast / diagnostic imaging*
  • Carcinoma, Intraductal, Noninfiltrating / diagnostic imaging*
  • Erb-b2 Receptor Tyrosine Kinases / metabolism
  • Female
  • Humans
  • Immunohistochemistry
  • Mammography*
  • Middle Aged
  • Retrospective Studies
  • Triple Negative Breast Neoplasms / diagnostic imaging*
  • Triple Negative Breast Neoplasms / metabolism

Substances

  • Erb-b2 Receptor Tyrosine Kinases
  • ERBB2 protein, human