Malaria Molecular Epidemiology: Lessons from the International Centers of Excellence for Malaria Research Network

Am J Trop Med Hyg. 2015 Sep;93(3 Suppl):79-86. doi: 10.4269/ajtmh.15-0005. Epub 2015 Aug 10.


Molecular epidemiology leverages genetic information to study the risk factors that affect the frequency and distribution of malaria cases. This article describes molecular epidemiologic investigations currently being carried out by the International Centers of Excellence for Malaria Research (ICEMR) network in a variety of malaria-endemic settings. First, we discuss various novel approaches to understand malaria incidence and gametocytemia, focusing on Plasmodium falciparum and Plasmodium vivax. Second, we describe and compare different parasite genotyping methods commonly used in malaria epidemiology and population genetics. Finally, we discuss potential applications of molecular epidemiological tools and methods toward malaria control and elimination efforts.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Gene Flow / genetics
  • Genetics, Population
  • Genotyping Techniques
  • Humans
  • International Cooperation
  • Malaria / epidemiology*
  • Malaria / genetics*
  • Malaria / prevention & control
  • Malaria / transmission
  • Malaria, Falciparum / epidemiology
  • Malaria, Falciparum / genetics
  • Malaria, Vivax / epidemiology
  • Malaria, Vivax / genetics
  • Molecular Epidemiology
  • Plasmodium / genetics*
  • Plasmodium falciparum / genetics
  • Plasmodium vivax / genetics