The Newly Identified T Helper 22 Cells Lodge in Leukemia

Gholamreza Azizi; Mohsen Rastegar Pouyani; Shadi Sadat Navabi; Reza Yazdani; Fatemeh Kiaee; Abbas Mirshafiey

The Newly Identified T Helper 22 Cells Lodge in Leukemia

Int J Hematol Oncol Stem Cell Res. 2015 Jul 1;9(3):143-54.

Authors

Gholamreza Azizi¹, Mohsen Rastegar Pouyani², Shadi Sadat Navabi², Reza Yazdani³, Fatemeh Kiaee⁴, Abbas Mirshafiey²

Affiliations

¹ Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran ; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
² Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
³ Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran ; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
⁴ Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 26261700
PMCID: PMC4529682

Abstract

Leukemia is a hematological tumor in which the malignant myeloid or lymphoid subsets play a pivotal role. Newly identified T helper cell 22 (Th22) is a subset of CD4(+) T cells with distinguished gene expression, function and specific properties apart from other known CD4(+) T cell subsets.Th22 cells are characterized by production of a distinct profile of effector cytokines, including interleukin (IL)-22, IL-13, and tumor necrosis factor-α (TNF-α). The levels of Th22 and cytokine IL-22 are increased and positively related to inflammatory and autoimmune disorders. Recently, several studies have reported the changes in frequency and function of Th22 in acute leukemic disorders as AML and ALL. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of leukemic disease.

Keywords: ALL; AML; IL-22; Leukemia; Th22.

Publication types

Review