Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs

Mar Drugs. 2015 Aug 7;13(8):5007-15. doi: 10.3390/md13085007.


N-acetyl-d-glucosamine (GlcNAc) is a monosaccharide that polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. GlcNAc is a basic component of hyaluronic acid and keratin sulfate found on the cell surface. The aim of this study was to examine amino acid metabolism after oral GlcNAc administration in dogs. Results showed that plasma levels of ectoine were significantly higher after oral administration of GlcNAc than prior to administration (p < 0.001). To our knowledge, there have been no reports of increased ectoine concentrations in the plasma. The mechanism by which GlcNAc administration leads to increased ectoine plasma concentration remains unclear; future studies are required to clarify this mechanism.

Keywords: N-acetyl-d-glucosamine hydrochloride; TGF-beta; amino acid; cartilage regeneration; dog.

MeSH terms

  • Acetylglucosamine / administration & dosage*
  • Administration, Oral
  • Amino Acids / metabolism
  • Amino Acids, Diamino / blood
  • Animals
  • Dogs
  • Metabolome / drug effects*
  • Metabolomics / methods
  • Monosaccharides / administration & dosage
  • Plasma / drug effects*
  • Plasma / metabolism*


  • Amino Acids
  • Amino Acids, Diamino
  • Monosaccharides
  • ectoine
  • Acetylglucosamine