Recommendations for post-surgical thyroid ablation in differentiated thyroid cancer: a 2015 position statement of the Italian Society of Endocrinology

J Endocrinol Invest. 2016 Mar;39(3):341-7. doi: 10.1007/s40618-015-0375-7. Epub 2015 Aug 12.


Post-surgical ablation of thyroid remnant with radioactive iodine (RAI) in differentiated thyroid cancer (DTC) is aimed to destroy any thyroid remnant in the thyroid bed (remnant ablation) and any microscopic foci of cancer cells eventually present within the thyroid remnant (adjuvant therapy). The present text is an attempt to offer practice guidelines for the indication of thyroid ablation and the preparation of DTC patients considering the latest achievement in the field and the changing epidemiology of DTC observed in the last 10 years.

Methodology: The executive committee of the Italian Society of Endocrinology appointed a task force of thyroid cancer expert including Nuclear Medicine Physicians and Endocrinologists to provide a consensus on the post-surgical ablation in thyroid cancer patients. The task force had no conflict of interest and had no commercial support. A number of specific topics were selected and the members selected relevant papers by searching in the Pubmed for articles published from 2000 to January 2015. Selected studies were categorized by level of evidence, and the recommendations were graded according to the level of evidence as high (A), moderate (B), or low (C).

Keywords: Radioiodine; Thyroglobulin; Thyroid ablation; Thyroid cancer; rhTSH.

MeSH terms

  • Adenocarcinoma / therapy*
  • Catheter Ablation*
  • Cell Differentiation*
  • Endocrinology
  • Humans
  • Italy
  • Postoperative Care
  • Practice Guidelines as Topic / standards*
  • Societies, Medical
  • Thyroid Neoplasms / therapy*