The scope and sequence of growth factor delivery for vascularized bone tissue regeneration

E A Bayer; R Gottardi; M V Fedorchak; S R Little

doi:10.1016/j.jconrel.2015.08.004

The scope and sequence of growth factor delivery for vascularized bone tissue regeneration

J Control Release. 2015 Dec 10;219:129-140. doi: 10.1016/j.jconrel.2015.08.004. Epub 2015 Aug 8.

Authors

E A Bayer¹, R Gottardi², M V Fedorchak³, S R Little⁴

Affiliations

¹ The University of Pittsburgh, Department of Bioengineering, USA; The University of Pittsburgh, The McGowan Institute for Regenerative Medicine, USA.
² The University of Pittsburgh, Department of Chemical Engineering, USA; The University of Pittsburgh, Department of Orthopedic Surgery, USA; The University of Pittsburgh, The McGowan Institute for Regenerative Medicine, USA; RiMED Foundation, Palermo, Italy.
³ The University of Pittsburgh, Department of Bioengineering, USA; The University of Pittsburgh, Department of Chemical Engineering, USA; The University of Pittsburgh, Department of Ophthalmology, USA; The University of Pittsburgh, The McGowan Institute for Regenerative Medicine, USA.
⁴ The University of Pittsburgh, Department of Bioengineering, USA; The University of Pittsburgh, Department of Chemical Engineering, USA; The University of Pittsburgh, Department of Immunology, USA; The University of Pittsburgh, The McGowan Institute for Regenerative Medicine, USA. Electronic address: srlittle@pitt.edu.

PMID: 26264834
DOI: 10.1016/j.jconrel.2015.08.004

Abstract

Bone regeneration is a complex process, that in vivo, requires the highly coordinated presentation of biochemical cues to promote the various stages of angiogenesis and osteogenesis. Taking inspiration from the natural healing process, a wide variety of growth factors are currently being released within next generation tissue engineered scaffolds (in a variety of ways) in order to heal non-union fractures and bone defects. This review will focus on the delivery of multiple growth factors to the bone regeneration niche, specifically 1) dual growth factor delivery signaling and crosstalk, 2) the importance of growth factor timing and temporal separation, and 3) the engineering of delivery systems that allow for temporal control over presentation of soluble growth factors. Alternative methods for growth factor presentation, including the use of gene therapy and platelet-rich plasma scaffolds, are also discussed.

Keywords: Biomaterials; Bone regeneration; Controlled release; Growth factors; Tissue engineering.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biocompatible Materials / administration & dosage
Bone Regeneration*
Drug Delivery Systems*
Humans
Intercellular Signaling Peptides and Proteins / administration & dosage*
Tissue Engineering

Substances

Biocompatible Materials
Intercellular Signaling Peptides and Proteins

Grant support

T32EB001026/EB/NIBIB NIH HHS/United States