Five New Guaiane Sesquiterpenes from the Endophytic Fungus Xylaria sp. YM 311647 of Azadirachta indica

Chem Biodivers. 2015 Aug;12(8):1281-6. doi: 10.1002/cbdv.201400405.

Abstract

Five new guaiane sesquiterpenes, 1-5, were isolated from the culture broth of the endophytic fungus Xylaria sp. YM 311647, isolated from Azadirachta indica A. Juss. The structures of these compounds were elucidated on the basis of spectroscopic analyses, and their inhibitory activities against five pathogenic fungi were evaluated. All guaiane sesquiterpenes showed moderate or weak antifungal activities in a broth microdilution assay.

Keywords: Antifungal activity; Endophytic fungi; Guaiane sesquiterpenes; Xylaria.

MeSH terms

  • Antifungal Agents / chemistry*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Azadirachta / microbiology*
  • Fungi / drug effects
  • Humans
  • Mycoses / drug therapy
  • Sesquiterpenes, Guaiane / chemistry*
  • Sesquiterpenes, Guaiane / isolation & purification
  • Sesquiterpenes, Guaiane / pharmacology*
  • Xylariales / chemistry*

Substances

  • Antifungal Agents
  • Sesquiterpenes, Guaiane