Corneal Cross-Linking for Brittle Cornea Syndrome

Cornea. 2015 Oct;34(10):1326-8. doi: 10.1097/ICO.0000000000000577.

Abstract

Purpose: To describe corneal cross-linking (CXL) as a treatment option for brittle cornea syndrome (BCS).

Methods: Case report.

Results: Ethical decision making enabled bilateral sequential transepithelial CXL in an 11-year-old girl with BCS. Postoperative courses were uneventful with a bilateral stromal demarcation line, unchanged corneal transparency, constant endothelial cell density, and stable topography 2 years after intervention.

Conclusions: Modified CXL can safely be performed in patients with BCS. Ethical review may be helpful for interventions deviating from standard practice.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Collagen / metabolism*
  • Corneal Stroma / metabolism*
  • Cross-Linking Reagents*
  • DNA-Binding Proteins / genetics
  • Eye Abnormalities / drug therapy*
  • Eye Abnormalities / genetics
  • Eye Abnormalities / metabolism
  • Female
  • Humans
  • Joint Instability / congenital*
  • Joint Instability / drug therapy
  • Joint Instability / genetics
  • Joint Instability / metabolism
  • Mutation
  • Photosensitizing Agents / therapeutic use*
  • Riboflavin / therapeutic use*
  • Skin Abnormalities / drug therapy*
  • Skin Abnormalities / genetics
  • Skin Abnormalities / metabolism
  • Transcription Factors / genetics
  • Ultraviolet Rays
  • Visual Acuity

Substances

  • Cross-Linking Reagents
  • DNA-Binding Proteins
  • PRDM5 protein, human
  • Photosensitizing Agents
  • Transcription Factors
  • Collagen
  • Riboflavin

Supplementary concepts

  • Brittle cornea syndrome 1