Organ Size Control: Lessons from Drosophila

Dev Cell. 2015 Aug 10;34(3):255-65. doi: 10.1016/j.devcel.2015.07.012.

Abstract

Of fundamental interest to biologists is how organs achieve a reproducible size during development. Studies of the developing Drosophila wing have provided many key insights that will help give a conceptual understanding of the process beyond the fly. In the wing, there is evidence for both "top-down" mechanisms, in which signals emanating from small subsets of cells direct global proliferation, and "bottom-up" mechanisms, in which the final size is an emergent property of local cell-cell interactions. Mechanical forces also appear to have an important role along with the Hippo pathway, which may integrate multiple types of inputs to regulate the extent of growth.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Communication / physiology
  • Cell Proliferation
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / growth & development*
  • Imaginal Discs / growth & development*
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Organ Size
  • Protein-Serine-Threonine Kinases / metabolism
  • Signal Transduction / physiology
  • Wings, Animal / growth & development*

Substances

  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • Protein-Serine-Threonine Kinases
  • hpo protein, Drosophila