PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?

Cancer Cell. 2015 Aug 10;28(2):143-5. doi: 10.1016/j.ccell.2015.07.010.

Abstract

In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequently inactivated in triple-negative breast cancers, functions as a tumor suppressor by specifically modulating the activity of AKT1 in the context of oncogenic PI3K signaling, leading to inhibition of metastatic dissemination.

Publication types

  • Comment

MeSH terms

  • Animals
  • Breast Neoplasms / genetics*
  • Cell Proliferation / genetics*
  • Humans
  • Phosphoric Monoester Hydrolases / genetics*
  • Proto-Oncogene Proteins c-akt / genetics*

Substances

  • Proto-Oncogene Proteins c-akt
  • Phosphoric Monoester Hydrolases