Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split-mouth randomized clinical trial

J Clin Periodontol. 2015 Sep;42(9):868-875. doi: 10.1111/jcpe.12444. Epub 2015 Sep 22.


Aim: The aim of this study was to determine the clinical effect of concentrated growth factor (CGF) in combination with coronally advanced flap (CAF) compared to CAF alone for the treatment of multiple adjacent gingival recessions (GRs).

Materials and methods: Twenty patients with a total of 119 Miller Class I and II GRs in the maxilla were included to this study. Recessions were randomly treated according to a split-mouth design by means of CAF + CGF (test; 60 defects) or CAF (control; 59 defects). Clinical outcomes were evaluated at baseline and 6 months after surgery.

Results: The mean root coverage (MRC) was 82.06% and 86.67%, complete root coverage (CRC) was 45.8% (27/59) and 56.7% (34/60) for CAF and CAF + CGF, respectively at 6th month. Statistically no difference was demonstrated between the two groups in terms of recession depth (RD), MRC and CRC at 6th month. The increase in width of keratinized gingiva (KGW) and gingival thickness (GT) were statistically significant in the CAF + CGF group compared to the CAF group at 6th month.

Conclusions: The use of CGF in combination with CAF did not provide additional benefits in RD, CRC and MRC. This study suggests that use of CGF + CAF may increase the success of GRs because of a significant increase in KGW and GT.

Keywords: concentrated growth factor; gingival recession; growth factor; plastic surgery; platelet-rich fibrin; root coverage.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Connective Tissue
  • Female
  • Follow-Up Studies
  • Gingival Recession / metabolism
  • Gingival Recession / therapy*
  • Gingivoplasty
  • Humans
  • Intercellular Signaling Peptides and Proteins / therapeutic use*
  • Male
  • Middle Aged
  • Prognosis
  • Surgical Flaps*
  • Tooth Root / surgery*
  • Young Adult


  • Intercellular Signaling Peptides and Proteins