Safety and Toxicology of Cannabinoids

Neurotherapeutics. 2015 Oct;12(4):735-46. doi: 10.1007/s13311-015-0380-8.


There is extensive research on the safety, toxicology, potency, and therapeutic potential of cannabis. However, uncertainty remains facilitating continued debate on medical and recreational cannabis policies at the state and federal levels. This review will include a brief description of cannabinoids and the endocannabinoid system; a summary of the acute and long-term effects of cannabis; and a discussion of the therapeutic potential of cannabis. The conclusions about safety and efficacy will then be compared with the current social and political climate to suggest future policy directions and general guidelines.

Keywords: Cannabis; Cannabis efficacy; Cannabis policy; Cannabis safety.

Publication types

  • Review

MeSH terms

  • Animals
  • Cannabinoids / adverse effects*
  • Cannabinoids / therapeutic use
  • Cannabis / toxicity*
  • Health Policy*
  • Humans
  • Marijuana Abuse / etiology
  • Toxicology*


  • Cannabinoids