Comparative mapping of host-pathogen protein-protein interactions

Curr Opin Microbiol. 2015 Oct;27:62-8. doi: 10.1016/j.mib.2015.07.008. Epub 2015 Aug 10.


Pathogens usurp a variety of host pathways via protein-protein interactions to ensure efficient pathogen replication. Despite the existence of an impressive toolkit of systematic and unbiased approaches, we still lack a comprehensive list of these PPIs and an understanding of their functional implications. Here, we highlight the importance of harnessing genetic diversity of hosts and pathogens for uncovering the biochemical basis of pathogen restriction, virulence, fitness, and pathogenesis. We further suggest that integrating physical interaction data with orthogonal types of data will allow researchers to draw meaningful conclusions both for basic and translational science.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Databases as Topic
  • Genetic Variation*
  • Host-Pathogen Interactions* / genetics
  • Humans
  • Protein Interaction Mapping*
  • Viral Proteins / metabolism*
  • Virulence / genetics


  • Bacterial Proteins
  • Viral Proteins