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, 8 (7), 538-42

Antimicrobial Activity and Synergism of Sami-Hyanglyun-Hwan With Ciprofloxacin Against Methicillin-Resistant Staphylococcus Aureus

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Antimicrobial Activity and Synergism of Sami-Hyanglyun-Hwan With Ciprofloxacin Against Methicillin-Resistant Staphylococcus Aureus

Jang-Gi Choi et al. Asian Pac J Trop Med.

Abstract

Objective: To investigate the antibacterial activity of SHH extracted with either water or ethanol against methicillin-resistant Staphylococcus aureus (MRSA) and combinatory antimicrobial effect with ciprofloxacin (CIP) by time kill assay and checkerboard dilution test.

Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan (SHH) water extract (SHHW) and SHH ethanol extract (SHHE) ranged from 250 to 2000 μg/mL and 125 to 1000 μg/mL against MRSA, respectively.

Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h.

Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.

Keywords: Ciprofloxacin; Methicillin-resistant Staphylococcus aureus; Sami-Hyanglyun-Hwan; Synergy.

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