B-acute lymphoblastic leukemia/lymphoblastic lymphoma

Am J Clin Pathol. 2015 Sep;144(3):393-410. doi: 10.1309/AJCPAN7BH5DNYWZB.


Objectives: This session of the 2013 Society of Hematopathology/European Association for Haematopathology Workshop was dedicated to B-acute lymphoblastic leukemia (B-ALL)/lymphoblastic lymphoma (LBL) with recurrent translocations and not otherwise specified.

Methods: In this review, we summarize the cases discussed during the workshop, review the pertinent and most recent literature on the respective topics, and provide a few key points that may aid in the workup of patients with B-ALL/LBL.

Results: Many of the submitted cases showed interesting diagnostic, immunophenotypic, or clinical aspects of B-ALL with BCR/ABL1, MLL-associated, and other recurrent chromosomal abnormalities. Several cases showed rare aberrancies such as coexistent IGH/BCL2 and MYC rearrangements and raised issues in classification. Other cases had unusual clinical presentations, including B-ALL with hypereosinophilia and therapy-related B-ALL. Several cases highlighted the role of flow cytometry immunophenotyping in distinguishing benign B-cell precursors from aberrant lymphoblasts, and other cases raised questions regarding the clinical importance of myeloperoxidase positivity in acute lymphoblastic leukemia.

Conclusions: The complexity and spectrum of cases presented in this review highlight the importance of clinicopathologic correlation and the value of ancillary studies in the classification and workup of patients with B-ALL/LBL.

Keywords: B-ALL; Cytogenetics; Flow cytometry immunophenotyping; Myeloid.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • Chromosome Aberrations*
  • Humans
  • Immunophenotyping / methods
  • Lymphoma, B-Cell / complications
  • Lymphoma, B-Cell / diagnosis
  • Lymphoma, B-Cell / pathology*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Precursor Cells, B-Lymphoid / cytology*