Genetics of Canine Primary Glaucomas

Vet Clin North Am Small Anim Pract. 2015 Nov;45(6):1159-82, v. doi: 10.1016/j.cvsm.2015.06.003. Epub 2015 Aug 13.


Primary glaucomas are a leading cause of incurable vision loss in dogs. Based on their specific breed predilection, a genetic cause is suspected to be responsible, and affected dogs should be excluded from breeding. Despite the high prevalence of primary glaucomas in dogs, their genetics have been studied in only a small number of breeds. The identification of canine glaucoma disease genes, and the development of genetic tests, will help to avoid the breeding of affected dogs in the future and will allow for earlier diagnosis and potentially more effective therapy.

Keywords: ADAMTS10; ADAMTS17; Canine; Closed-angle; Genetics; Glaucoma; Lens luxation; Open-angle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dog Diseases / genetics*
  • Dogs
  • Genetic Predisposition to Disease*
  • Glaucoma / genetics
  • Glaucoma / veterinary*