Acute eosinophilic pneumonia associated with glyphosate-surfactant exposure

Sarcoidosis Vasc Diffuse Lung Dis. 2015 Jul 22;32(2):172-5.


We report a case of a female patient who developed acute eosinophilic pneumonia (AEP) after recent onset of smoking and exposure to glyphosate-surfactant.The additional exposure associated with the recent start of smoking may have contributed to the development and/or severity of AEP.A clinical relapse after re-challenge four years later both with smoking and glyphosate-surfactant made the association highly likely.Respiratory distress is a factor of poor outcome and mortality after ingestion of glyphosate-surfactant.This case highlights the importance of a thorough exposure history e.g., possible occupational and environmental exposures together with drug-intake.Genotyping should be considered in cases of severe unexplained pulmonary damage.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Acute Disease
  • Adult
  • Bronchoalveolar Lavage Fluid / cytology*
  • Environmental Exposure / adverse effects
  • Female
  • Glycine / adverse effects
  • Glycine / analogs & derivatives*
  • Glyphosate
  • Humans
  • Monitoring, Physiologic
  • Multidetector Computed Tomography / methods
  • Prognosis
  • Pulmonary Eosinophilia / chemically induced*
  • Pulmonary Eosinophilia / diagnosis*
  • Radiography, Thoracic / methods
  • Risk Assessment
  • Smoking / adverse effects
  • Surface-Active Agents / adverse effects*


  • Surface-Active Agents
  • Glycine