Continuous Positive Airway Pressure in Patients With Obstructive Sleep Apnea and Resistant Hypertension: A Meta-Analysis of Randomized Controlled Trials

J Clin Hypertens (Greenwich). 2016 Feb;18(2):153-8. doi: 10.1111/jch.12639. Epub 2015 Aug 17.


This study aimed to analyze the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with obstructive sleep apnea (OSA) and resistant hypertension. Randomized controlled trials (RCTs) that evaluated the effect of CPAP on BP in patients with OSA and resistant hypertension, indexed in MEDLINE, Embase, and the Cochrane Library from inception until March 20, 2015, were included in the meta-analysis. A total of five RCTs were identified to meet the inclusion criteria. The pooled changes after CPAP treatment for 24-hour ambulatory systolic BP and diastolic BP (DBP) were -4.78 mm Hg (95% confidence interval [CI], -7.95 to -1.61) and -2.95 mm Hg (95% CI, -5.37 to -0.53) in favor of the CPAP group. CPAP was also associated with reduction in nocturnal DBP (mean difference, -1.53 mm Hg, 95% CI, -3.07 to 0). The results indicated a favorable reduction in BP with CPAP treatment in patients with OSA and resistant hypertension.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Continuous Positive Airway Pressure / methods*
  • Drug Resistance
  • Humans
  • Hypertension* / complications
  • Hypertension* / therapy
  • Hypoglycemic Agents / therapeutic use*
  • Outcome and Process Assessment, Health Care
  • Randomized Controlled Trials as Topic
  • Sleep Apnea, Obstructive* / complications
  • Sleep Apnea, Obstructive* / therapy


  • Hypoglycemic Agents