Antihypertensive and neuroprotective actions of pyridoxine and its derivatives

Can J Physiol Pharmacol. 2015 Dec;93(12):1083-90. doi: 10.1139/cjpp-2015-0098. Epub 2015 May 11.


Vitamin B6 plays a crucial role in the nervous system as the amino acid decarboxylases involved in the synthesis of all putative neurotransmitters requires the coenzyme pyridoxal phosphate. Vitamin B6 in its various forms has antioxidant properties. Pyridoxal phosphate has a role in regulating cellular calcium transport through both the voltage-mediated and ATP-mediated purinergic mechanisms of cellular calcium influx and, hence, has a role in the control of hypertension. Pharmacological doses of vitamin B6 appear to decrease the high blood pressure associated with both genetic and nongenetic models of hypertension. Vitamin B6 has a crucial role in the normal function of the central and peripheral nervous systems. It also protects against ischemia and glutamate-induced neurotoxicity.

Keywords: GABA; acide domoïque; calcium influx; catecholamines; catécholamines; domoic acid; hypertension; influx de calcium; neuroprotection; pyridoxal phosphate; serotonin; sérotonine.

Publication types

  • Review

MeSH terms

  • Animals
  • Antihypertensive Agents / pharmacology*
  • Antihypertensive Agents / therapeutic use*
  • Humans
  • Hypertension / drug therapy
  • Neuroprotective Agents / pharmacology*
  • Neuroprotective Agents / therapeutic use*
  • Pyridoxal Phosphate / pharmacology
  • Pyridoxal Phosphate / therapeutic use
  • Pyridoxine / pharmacology*
  • Pyridoxine / therapeutic use*
  • Vitamin B 6 / pharmacology
  • Vitamin B 6 / therapeutic use


  • Antihypertensive Agents
  • Neuroprotective Agents
  • Pyridoxal Phosphate
  • Vitamin B 6
  • Pyridoxine