Urinary oxalate recovery after oral oxalic load: an alternative method to the quantitative determination of stool fat for the diagnosis of lipid malabsorption

J Int Med Res. Nov-Dec 1989;17(6):526-31. doi: 10.1177/030006058901700605.

Abstract

Urinary oxalate concentrations were measured in 45 patients with quiescent Crohn's disease, four patients with chronic pancreatitis and five healthy subjects after a normal oxalate (150 g/day) diet, after a high-fat (150 g/day), normal oxalate diet and after and after a high-oxalate (500 mg/day) diet. Urinary oxalate concentrations were significantly (P less than 0.05) higher in patients with Crohn's disease and steatorrhoea, but not in those with chronic pancreatitis, after administrating a high-oxalate diet compared with healthy subjects. Mean oxalate values were 19.1 mg/24 h in controls compared with 65.8 mg/24 h in Crohn's disease patients. A direct correlation (r = 0.37, P less than 0.01) was established between faecal rats and urinary oxalate after oval oxalate load: this correlation (r = 0.43, P less than 0.01) is closer when only patients with Crohn's disease are considered. The study, therefore, confirmed a correlation between steatorrhoea and hyperoxaluria in patients with Crohn's disease; however, the high percentage of false positive results limits the use of urinary oxalate concentrations as a reliable indicator of lipid malabsorption. It is concluded that, at present, measurement of urinary oxalate cannot be recommended as a valid alternative to the Van de Kamer method for diagnosing lipid malabsorption.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Celiac Disease / diagnosis*
  • Celiac Disease / etiology
  • Celiac Disease / urine
  • Chronic Disease
  • Colon / surgery
  • Crohn Disease / complications
  • Crohn Disease / metabolism
  • Crohn Disease / surgery
  • Feces / analysis*
  • Female
  • Humans
  • Ileum / surgery
  • Lipids / analysis*
  • Male
  • Middle Aged
  • Oxalates* / urine
  • Pancreatitis / metabolism

Substances

  • Lipids
  • Oxalates