Generalized seizures in a neural field model with bursting dynamics

J Comput Neurosci. 2015 Oct;39(2):197-216. doi: 10.1007/s10827-015-0571-7. Epub 2015 Aug 19.

Abstract

The mechanisms underlying generalized seizures are explored with neural field theory. A corticothalamic neural field model that has accounted for multiple brain activity phenomena and states is used to explore changes leading to pathological seizure states. It is found that absence seizures arise from instabilities in the system and replicate experimental studies in numerous animal models and clinical studies.

Keywords: Corticothalamic; Generalized seizures; Neural-field theory.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Animals
  • Axons / drug effects
  • Axons / physiology
  • Computer Simulation
  • Dendrites / drug effects
  • Dendrites / physiology
  • Fourier Analysis
  • Humans
  • Models, Neurological*
  • Nerve Net / physiopathology
  • Neurons / cytology
  • Neurons / physiology*
  • Nonlinear Dynamics*
  • Seizures / pathology*
  • Thalamus / cytology
  • Thalamus / physiology
  • gamma-Aminobutyric Acid

Substances

  • gamma-Aminobutyric Acid