Tissue instruction for migration and retention of TRM cells

Trends Immunol. 2015 Sep;36(9):556-64. doi: 10.1016/j.it.2015.07.002. Epub 2015 Aug 14.


During infection, a subset of effector T cells seeds the lymphoid and non-lymphoid tissues and gives rise to tissue-resident memory T cells (TRM). Recent findings have provided insight into the molecular and cellular mechanisms underlying tissue instruction of TRM cell homing, as well as the programs involved in their retention and maintenance. We review these findings here, highlighting both common features and distinctions between CD4 TRM and CD8 TRM cells. In this context we examine the role of memory lymphocyte clusters (MLCs), and propose that the MLCs serve as an immediate response center consisting of TRM cells on standby, capable of detecting incoming pathogens and mounting robust local immune responses to contain and limit the spread of infectious agents.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Survival / immunology
  • Chemokines / metabolism
  • Host-Pathogen Interactions / immunology
  • Humans
  • Immunologic Memory*
  • Leukocyte Rolling / immunology
  • Lymphocyte Activation / immunology
  • Lymphoid Progenitor Cells / cytology
  • Lymphoid Progenitor Cells / immunology
  • Lymphoid Progenitor Cells / metabolism
  • Organ Specificity / immunology
  • Signal Transduction
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism*
  • Transendothelial and Transepithelial Migration / immunology


  • Chemokines